RedShift BioAnalytics has developed a powerful new analytical technique called Microfluidic Modulation System, or MMS, that at long last enables the optical detection of very low levels of analytes in fluids. When applied to the detection of protein therapeutics, MMS provides the direct measurement, at the native concentrations, of a protein’s underlying biophysical structures. By harnessing the optical power and tunability of lasers, and the precision of fluidic modulation, MMS can rapidly measure a protein sample and its reference buffer in a single microfluidic cell.
Using the optical power of the laser to achieve a large improvement in measurement path length, MMS dramatically increases sensitivity across a broad range of protein concentrations. The result is a higher signal-to-noise ratio, better reproducibility, a more robust measurement and, most importantly, better science. A single instrument can now provide a simultaneous, direct, and label free approach to measuring the unfolding / folding process of the protein in each stage of development.