Physicochemical Characterization of Antibody-Drug Conjugates:
Webinar Length: 1 hour
Broadcast Date: May 13, 2021
Time: 11am EST
In this webinar you will learn:
- Analysis of the higher of structure (HOS) of therapeutic antibodies and antibody drug conjugates.
- Study of the effects in secondary structure of conjugated proteins.
- How the AQS3pro, with Microfluidic Modulation Spectroscopy, provides reliability, increased sensitivity and higher resolution for secondary structure analysis of biotherapeutics.
Antibodies are the most rapidly growing form of therapeutic. High-throughput methods of characterization are essential as companies and researchers move to develop new candidates. In this webinar, Dr. Shawn Owen discusses advanced characterization techniques to assess antibody-drug conjugates (ADCs). For ADCs, the level of payload and site of conjugation are determined using LC/MS. Thermal stability and binding affinity are characterized using DSC, IR, and ITC. These methods can be used for the in-depth analysis of these biologics and for routine product validation.
Shawn C. Owens, Ph.D.
Assistant Professor in Pharmaceutics and Pharmaceutical Chemistry and Adjunct Professor of Biomedical Engineering, at The University of Utah
Shawn C. Owens, Ph.D., Assistant Professor in Pharmaceutics and Pharmaceutical Chemistry and Adjunct Professor of Biomedical Engineering
Shawn C. Owen, Ph.D. is an Assistant Professor in Pharmaceutics and Pharmaceutical Chemistry and Adjunct Professor of Biomedical Engineering; of Medicinal Chemistry, and of Internal Medicine at the University of Utah. He is also a member of the Huntsman Cancer Institute Experimental Therapeutics Program and the Nano-Institute of Utah. Dr. Owen’s research focuses on evaluating the pharmaceutic stability of antibody-based therapeutics, creating antibody-drug conjugates (ADCs) that induce self-amplifying therapeutic cascades, and engineering antibody-split enzyme systems for diagnostic applications. He has published more than thirty research papers on drug delivery and biotechnology, and his research has produced four patent applications. Dr. Owen is recognized with several prominent university teaching awards and is sought for outreach workshops by both academic and industry sponsors.