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Keep up-to-date on the latest developments in MMS, biophysical characterization and RedShiftBio by regularly visiting us here. On this page you will find our comprehensive resources, highlights from new papers and other interesting materials that will help you characterize proteins.

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Posters

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Pressure-perturbation of protein secondary structure coupled with Microfluidic Modulation Spectroscopy – a powerful platform for biopharmaceutical formulations development

Vera Gross, Gary Smejkal, Nicole Cutri, Alexander Lazarev (Pressure Biosciences) Libo Wang, John Linnan, Matthew McGann, Jeffrey Zonderman, (RedShiftBio)

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Comparability, Similarity, Linearity and High Order Structure Analysis of an IgG1 Sample by Microfluidic Modulation Spectroscopy

Libo Wang, Lucy Liu, Jason Rouse, Eugene Ma and Jeffery Zonderman RedShift BioAnalytics, Inc, Pfizer, Inc.

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Microfluidic Modulation Spectroscopy (MMS) - a novel automated infrared (IR) spectroscopic tool for secondary structure analysis of biopharmaceuticals with high sensitivity and repeatability.

Dipanwita Batabyal, Harrison Lord, and Mats Wikström, Attribute Sciences, Amgen Inc, and Libo Wang, John Linnan and Jeffrey Zonderman,RedshiftBio

Microfluidic Modulation Spectroscopy Analysis

Microfluidic Modulation Spectroscopy Analysis of a Monoclonal Antibody at Different Concentrations.

Libo Wang RedShiftBio, Ioannis A. Papayannopoulos Celldex

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Structural Characterization of the Insulin-Degrading Enzyme by Microfluidic Modulation Spectroscopy.

Valerie Ivancic, Clark University & Libo Wang, RedShiftBio

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Early Events in Amyloid Formation by Lysozyme Detected by Microfluidic Modulation Spectroscopy.

Quichen Zheng, Clark University & Libo Wang, RedShiftBio

Biotherapeutic

Microfluidic Modulation Spectroscopy of a Biotherapeutic at Low to High Concentrations without Interference from Formulation Excipients.

Libo Wang and Jeffrey Zonderman, RedShiftBio, and Ioannis A. Papayannopoulos and Shannon Renn-Bingham, Celldex

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HOS Study for IgG Samples Spiked with Different Amount of BSA by MMS.

Libo Wang, RedShiftBio & Brent Kendrick, Elion Labs

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Thermal Denaturation Analysis of Bovine Serum Albumin by Microfluidic Modulation Spectroscopy.

Lucy Liu, Pfizer

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Repeatability , Concentration Linearity and High Order Structure Analysis of an IgG1 Sample by Microfluidic Modulation Spectroscopy (MMS).

Libo Wang, RedShiftBio & Lucy Liu, Pfizer

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Enhanced Protein Structural Characterization using MMS.

Eugene Ma, RedShiftBio

Presentations & webinars

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Watch Our Webinar Replay with Elion Labs

“Using Microfluidic Modulation Spectroscopy to Monitor Protein Misfolds and Structural Similarity”

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Watch Eugenes PEGS Presentation

Eugene Ma Unveils RedShiftBio's AQS3pro Protein Characterization Instrument

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Watch Our Webinar Replay with Amgen

An Automated, Higher Performance Infrared (IR) Technology For Structural Analysis of Protein Biopharmaceuticals

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Watch Our Webinar Replay with ImmunoGen, Inc and Celldex Therapeutics

"Antibodies and Antibody-Drug Conjugate Higher Order Structures Revealed"

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Watch Our Webinar Replay with Janssen

Conformation Change of a Monoclonal Antibody in Real Time, Mimicking Low pH Hold Viral Inactivation

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Watch Our On Demand Webinar With Pressure BioSciences

Next-Gen IR Spectroscopy of Protein Structure Perturbed by Pressure

Articles

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A team led by Brent Kendrick at KBI Biopharma, compare and assess FTIR and Circular Dichroism with Microfluidic Modulation Spectroscopy (RedShiftBio) for their ability to detect the presence and quantify the amount of the misfolded structure. in this Journal of Pharmaceutical Sciences paper

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Pharmaceutical Technology North America interviews thought leaders (including Jeff Zonderman) for a feature on accepting the challenge of protein characterization

Matthew McGann

With the requirements of formulation development of biopharmaceuticals becoming more demanding, the evolution of analytical tools that can measure stability over a wide concentration range, in the presence of complex buffer systems is critical. Read this article in Drug Developmnet & Delivery to understand more about the role that MMS plays in formulation development.

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A team led by researchers at the University of Washington has developed synthetic peptides that target and inhibit the small, toxic protein aggregates that are thought to trigger Alzheimer's disease

Biopharm int

Biopharm International interviews scientists with experience of Microfluidic Modulation Spectroscopy for a round-table on how complex protein studies demand dynamic techniques. Visit page 18 to see what Immunogen, Janssen, Elion Labs and the University of Delaware have to say.

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Spectroscopy NA publishes an article in its IR Supplement from Celldex and RedShiftBio on native measurement of a biotherapeutic without interference from excipients using MMS

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American Laboratory publishes article on The Evolution of Spectroscopy by Brent Kendrick of Elion Labs and Eugene Ma and Libo Wang of RedShiftBio.

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American Pharmaceutical Review publishes article on MMS by Karan K. Shah Principal Development Associate Analytical and Pharmaceutical Sciences ImmunoGen, Inc.

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Instrument Business Outlook interviews RedShiftBio CCO Jeff Zonderman on the launch of the AQS3pro.

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Spec EU Spectroscopy Europe highlights the launch of the AQS3pro.

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Spectroscopy North America publishes peer-reviewed paper on MMS from Brent Kendrick of Elion Labs, Eugene Ma and Libo Wang of RedShiftBio.

Whitepapers, Application & Technical Notes

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MMS For Protein Therapeutic Drug Analysis - White Paper

This whitepaper provides an overview of RedShiftBio’s Microfluidic Modulation Spectroscopy technology and the performance that can be achieved in protein characterization. Specifically the white paper presents significant increases in sensitivity and concentration range for determining protein similarity (fingerprinting), quantitation, protein secondary structure, and protein stability and aggregation through thermal and chemical denaturation methods

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Microfluidic Modulation Spectroscopy (MMS) Fills an Analytical Gap with a Lower LOQ for Measuring Protein Misfolds and Structural Similarity

Common structural characterization methods such as FTIR and CD have known limitations in reproducibility and sensitivity which adversely increase the lowest level of quantitation (LOQ) achievable when measuring structural impurities and similarity. This application note will highlight the MMS system developed by RedShiftBio, a new protein characterization method which generates reproducible high resolution measurements. Demonstrated here, across a structural impurity range of 0–10%, are lower LOQ values compared to those possible using FTIR and CD.

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Thermal Denaturation Analysis of Bovine Serum Albumin over Wide Concentration Range by Microfluidic Modulation Spectroscopy

In this note, MMS was used to study the heat-induced thermal denaturation of BSA. The results show replicate measurements are very reproducible (99% similarity), and that MMS provides accurate secondary structure measurements for protein samples over a wide concentration range
(1 to 100 mg/mL).

Monoclonal-Antibody-Analysis

Monoclonal Antibody Analysis by Microfluidic Modulation Spectroscopy in a Complex Formulation Buffer (1 to 150 mg/mL)

This note demonstrates that MMS enables quantitative analysis of monoclonal antibodies over a wide concentration range with high reproducibility and accuracy.

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RedShiftBio™

RedShiftBio™ is an innovative provider of analytical instrumentation for the research, development and manufacturing of protein therapeutic drugs.

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RedShift BioAnalytics Inc.

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