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Keep up-to-date on the latest developments in MMS, biophysical characterization and RedShiftBio by regularly visiting us here. On this page you will find our comprehensive resources, highlights from new papers and other interesting materials that will help you characterize proteins.

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HOS Study for IgG Samples Spiked with Different Amount of BSA by MMS (Libo Wang, RedShiftBio & Brent Kendrick, Elion Labs)

To evaluate the sensitivity of MMS to detect small differences in secondary structure, absorbance spectra are analyzed for protein samples containing BSA spiked into IgG. Results show that MMS is a powerful technique for the measurement and analysis of protein secondary structure and provides HOS data with high sensitivity and accuracy.

Microfluidic Modulation Spectroscopy Analysis

Microfluidic Modulation Spectroscopy Analysis of a Monoclonal Antibody at Different Concentrations ( Libo Wang RedShiftBio, Ioannis A. Papayannopoulos Celldex )

To evaluate the data quality and performance of MMS, a monoclonal antibody formulated at relatively high concentration, was analyzed using MMS at different concentrations from 1 mg/mL to 150 mg/mL. Results show that the differential absorbance spectra (diffAU) of replicates for each
sample are very closely matched indicating high repeatability and accuracy of the measurements.

Thermal Denaturation Analysis of Bovine Serum Albumin by Microfluidic Modulation Spectroscopy (Lucy Liu, Pfizer)

MMS, a novel mid-IR technique, was used to monitor the thermal denaturation of Bovine Serum Albumin (BSA). Results show that MMS is a powerful technique for the measurement and analysis of protein secondary structure in samples over the wide concentration range of protein concentrations, up to 100 mg/mL.


Structural Characterization of the Insulin-Degrading Enzyme by Microfluidic Modulation Spectroscopy (Valerie Ivancic, Clark University & Libo Wang, RedShiftBio)

We used a new bioanalytical technique called Microfluidic Modulation Spectroscopy to directly probe the backbone structure of IDE in the absence and presence of ATP and insulin. Together, our results show that the interaction of ATP with IDE is localized to sidechains but the interaction of insulin with IDE leads to a perturbation in the backbone structure of the enzyme.


Repeatability , Concentration Linearity and High Order Structure Analysis of an IgG1 Sample by Microfluidic Modulation Spectroscopy (MMS) (Libo Wang, RedShiftBio & Lucy Liu, Pfizer)

To evaluate the data quality and performance of MMS, an IgG1 sample was analyzed at different concentrations ranging from 0.1 mg/mL to 12.3 mg/mL. MMS has proved to be a powerful protein characterization technique to provide comparability, similarity, quantitation linearity and HOS measurements of protein samples.


Early Events in Amyloid Formation by Lysozyme Detected by Microfluidic Modulation Spectroscopy (Quichen Zheng, Clark University & Libo Wang, RedShiftBio)

We used Microfluidic Modulation Spectroscopy (MMS) to characterize the early events in the self-assembly of human lysozyme. Through MMS, we were able to probe the mid-IR absorption band of the protein which is sensitive to both α-helix and β-structure. Results suggest that the first structural transition in the self-assembly of human lysozyme is an α-helix to β-structure conformational rearrangement.


Enhanced Protein Structural Characterization using MMS (Eugene Ma, RedShiftBio)

Introduction to Microfluidic Modulation Spectroscopy (MMS). This technology shows significant increases in sensitivity, dynamic range, accuracy and utility for determination of protein secondary structure, quantitation, similarity, stability and aggregation.

Presentations & Webinars

Watch Our Webinar Replay

“Using Microfluidic Modulation Spectroscopy to Monitor Protein Misfolds and Structural Similarity”

Watch Eugenes PEGS Presentation

Eugene Ma Unveils RedShiftBio's AQS3pro Protein Characterization Instrument

"Antibodies and Antibody-Drug Conjugate Higher Order Structures Revealed"


  • Am Lab

    American Laboratory publishes article on The Evolution of Spectroscopy by Brent Kendrick of Elion Labs and Eugene Ma and Libo Wang of RedShiftBio...Read More

  • Biopharm int

    Biopharm International interviews scientists with experience of Microfluidic Modulation Spectroscopy for a round-table on how complex protein studies demand dynamic techniques. Visit page 18 to see what Immunogen, Janssen, Elion Labs and the University of Delaware have to say.

  • american-pharam-review-cover

    American Pharmaceutical Review publishes article on MMS by Karan K. Shah Principal Development Associate Analytical and Pharmaceutical Sciences ImmunoGen, Inc. Read more>

  • Spec NA

    Spectroscopy North America publishes peer-reviewed paper on MMS from Brent Kendrick of Elion Labs, Eugene Ma and Libo Wang of RedShiftBio Read more>

  • IBO

    Instrument Business Outlook interviews RedShiftBio CCO Jeff Zonderman on the launch of the AQS3pro Read more>

  • Spec EU

    Spectroscopy Europe highlights the launch of the AQS3pro Read more>

Whitepapers, Application & Technical Notes


MMS For Protein Therapeutic Drug Analysis - White Paper

This whitepaper provides an overview of RedShiftBio’s Microfluidic Modulation Spectroscopy technology and the performance that can be achieved in protein characterization. Specifically the white paper presents significant increases in sensitivity and concentration range for determining protein similarity  (fingerprinting), quantitation, protein secondary structure, and protein stability and aggregation through thermal and chemical denaturation methods


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RedShiftBio™ is an innovative provider of analytical instrumentation for the research, development and manufacturing of protein therapeutic drugs.

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MMS For Protein Therapeutic Drug Analysis

Enhanced Protein Structural Characterization using MMS

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