Biophysical Characterization of RNA
Unlock Deeper Insights into RNA Structure and Stability
Discover the next generation of RNA analysis with Aurora TX, powered by Microfluidic Modulation Spectroscopy (MMS). RedShiftBio's ultra-sensitive platform enables precise, real-time structural characterization of RNA across a wide concentration range—supporting critical decisions in biopharma and vaccine development.
Why Choose MMS for RNA Characterization?
Traditional spectroscopic techniques like Circular Dichroism (CD) and FTIR fall short when it comes to sensitivity, reproducibility, and automation. MMS overcomes these limitations by delivering background-subtracted IR measurements in native buffers with walk-away automation and thermal ramping capabilities.
Aurora TX delivers:
- Real-time detection of subtle RNA structural changes
- Sensitivity across concentrations from 0.1 to >200 mg/mL
- Compatibility with RNA formulations, sequences, and LNP payloads
- Fully automated analysis with delta software integration
Application Spotlight: Riboswitch Characterization
In collaboration with Arrakis Therapeutics, MMS was used to study the structural changes of the SAM-I riboswitch upon ligand binding. This analysis provided:
- A detailed structural profile of the riboswitch
- Measurement of conformational changes in response to ligand interaction
- Apparent Kd values for ligand binding
These results demonstrate MMS's unique ability to connect RNA structure and function, providing insights critical to the design of RNA-targeted therapeutics.
Use Cases for RNA Characterization with MMS
Researchers and drug developers can rely on MMS for:
- Characterizing RNA folding and stability under thermal stress
- Comparing RNA sequences or batches for structural consistency
- Detecting structural effects of encapsulation or sequence modification
- Monitoring ligand-induced structural changes in riboswitches or other regulatory elements
Designed for Biopharma and RNA Therapeutics
Aurora TX is engineered to meet the needs of RNA researchers, vaccine developers, and therapeutic innovators. Whether you're formulating an mRNA vaccine or exploring small-molecule RNA modulators, MMS enables fast, reproducible structural insights to accelerate development and reduce risk.
RNA Characterization Resources
Explore More Applications
Ready to Advance Your RNA Analysis?
Request a Demo of Aurora TX and explore how MMS technology can elevate your RNA therapeutic development.
