Technology
Higher Quality Data, More Confident Decision-Making
RedShiftBio technologies deliver highly accurate results with the sensitivity, automation, and speed not possible with conventional techniques. This means you’ll have a clearer view of what’s happening with your process and your biomolecule exactly when you need it. Remove the delays, minimize the guesswork, say goodbye to bottlenecks. High-quality and high-resolution data to inform your decisions are now at your fingertips.
Microfluidic Modulation Spectroscopy
Protein higher order structure is a critical quality attribute that must be assessed as part of the drug development process and is essential to understanding the function of a given biomolecule. The ability to assess protein structure, stability, and aggregation under biologically/ pharmacologically relevant concentrations and buffer/formulation conditions yields much more relevant information about the proteins, antibodies, peptides, and other biomolecules being studied. Discovering your protein or biologic drug is unstable or prone to aggregation too late in development is a very costly and avoidable scenario.
Microfluidic Modulation Spectroscopy (MMS) enables direct, label-free analysis of the secondary structure of proteins over a wide concentration range (0.1 – 200 mg/mL) in complex formulation buffers without the need for buffer exchange or dilution. With MMS, you’ll see changes in biomolecule attributes that are missed by other technologies while gaining critical insights across all phases of drug development and manufacturing.
Purpose-built Liquid Chromatography
Accurate and reliable measurement of antibody concentration during process development and manufacturing is essential. While HPLC sets the standard for accuracy and dynamic range, the turnaround for results can be 24 hours or more, creating costly hold times and bottlenecks, and eliminating the ability to make real-time decisions.
In contrast, the simple and purpose-built liquid chromatography solution provided by HaLCon delivers on-demand antibody titer measurements over a wide dynamic range of 0.1 – 10 g/L in just minutes with an accuracy that strongly correlates with off-line HPLC. This speed and accuracy supports real-time decision-making and continuous bioprocessing.
See how purpose-built protein A affinity chromatography compares to HPLC.
Simulated Cell Culture Titer
HaLCon vs HPLC Titer Correlation
Related HaLCon Resources
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