HOS 2019 highlighted the range of biophysical characterization methods and tools used in monitoring the attributes of protein therapeutics such as conformation and higher order structure. We showcased AQSpro with Microfluidic Modulation Spectroscopy (MMS), a system that addresses the limitations of current products such as FTIR, and provides an efficient tool for direct, label-free protein analysis.
Amgen presented a poster at the conference, on the sensitivity of MMS for secondary structure analysis of biopharmaceuticals. The results show that high similarity scores (>99%), and consistent HOS analysis of secondary structure across different datasets confirms that PS 80 has no effect on the secondary structure of the mAb. Check out the poster to learn more.