PEGS Europe 2022: Measuring Change in Secondary Structure and Oligomeric State for a mAb in Stress and In-Process Testing with MMS and SEC

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‍Measuring Change in Secondary Structure and Oligomeric State for a mAb in Stress and In-Process Testing with MMS and SEC

Microfluidic Modulation Spectroscopy (MMS) is a new type of Mid-Infrared (MIR) spectroscopy with better sensitivity than traditional MIR and the ability to automate the measurement of samples over a large concentration range. In this talk, we examine the use of MMS to determine the secondary structure of stressed and in-process mAb samples and link these changes to aggregation of the target mAb as seen by size-exclusion chromatography (SEC).

Speaker: Daniel Myatt, PhD - Senior Scientist, Centre for Process Innovation (UK)