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RedShiftBio Exhibits at Well Characterized Biologics & Biological Assays 2019

We are exhibiting at Well Characterized Biologics & Biological Assays 2019 in Reston, VA (Nov 11-13, 2019). The 2019 meeting will discuss strategies for optimizing characterization and bioassay development. Come and see us at booth 25 to learn how the award-winning AQS3pro enables characterization of protein secondary structure.

The AQS3pro at Well Characterized Biologics & Biological Assays 2019

RedShiftBio will be showcasing the microfluidic modulation spectroscopy (MMS)-based AQS3pro at the meeting. The AQS3pro directly addresses the limitations of current structural analysis technologies (FTIR, CD-UV, etc). It provides an unmatched dynamic range, increased sensitivity, and fully automated operation. See change in your proteins with the AQS3pro.
We are presenting a poster at the conference. Come meet with representatives from both RedShiftBio and Pressure Biosciences to learn about pressure-perturbation of protein secondary structure coupled with Microfluidic Modulation Spectroscopy – a powerful platform for biopharmaceutical formulation development.

Book a meeting with us to learn more

Abstract

High hydrostatic pressure is a thermodynamic driver causing unfolding of proteins orthogonal to the action of temperature or various chaotropic reagents. Pressure effects on protein conformation are explained by hydration of solvent-excluded cavities that are populated with solvent upon unfolding.

Infrared spectroscopy, along with circular dichroism and fluorescence, is a popular method for monitoring protein structure changes. Recently introduced Microfluidic Modulation Spectroscopy (MMS) represents a major advancement of infrared spectroscopy specifically developed to simplify protein structure analysis. Pressure effects on proteins is highly reproducible and can be controlled very precisely. Pressure perturbation approach coupled with MMS can be used to study stability of human immunoglobulins as a model system for formulations development of monoclonal antibody products and other biopharmaceuticals.

In this study we demonstrate that pressure unfolding of human immunoglobulins in specific chemical environments promotes quantitative conversion of parallel beta sheet structures to the anti-parallel beta structures, a characteristic indicator of amyloid protein aggregation. We explore pressure effects on aggregation kinetics in a series of co-solvents, chaotropes and popular stabilizing excipients. Pressure perturbation approach coupled with MMS can be used to study stability of human immunoglobulins as a model system for formulations development of monoclonal antibody products and other biopharmaceuticals.

Well Characterized Biologics & Biological Assays 2019

The 2019 event will feature:

  • Practical advice from case studies, FDA & regulatory leaders to accelerate your biologics & novel modalities/molecules to market
  • 200+ attendees (scientists, executives, and regulators)
  • 58 speakers
  • 3 keynote presentations (Bluebirdbio, Celgene and Global Biotech Experts)

Come see us on booth 25 or, pre-book a meeting with our team for during the conference