Learn More About Microfluidic Modulation Spectroscopy

Keep up-to-date on the latest developments in Microfluidic Modulation Spectroscopy (MMS), biophysical characterization and RedShiftBio by regularly visiting us here. On this page you will find our comprehensive resources, highlights from new papers and other interesting materials that will help you characterize proteins.

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Webinars

Automated Analysis of Protein Secondary Structure Changes Due To Ligand Binding Using Microfluidic Modulation Spectroscopy

Automated Analysis of Protein Secondary Structure Changes Due To Ligand Binding Using Microfluidic Modulation Spectroscopy

Automated Analysis of Protein Secondary Structure Changes Due To Ligand Binding Using Microfluidic Modulation Spectroscopy Webinar Length: 1 hour Broadcast Date: April 6, 2021 Time: 1pm EST Host: CHI   In this webinar you will learn: The importance of determining the secondary structure of proteins with and without ligands for a more complete understanding of … “Automated Analysis of Protein Secondary Structure Changes Due To Ligand Binding Using Microfluidic Modulation Spectroscopy”

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HOS biocompatibility by MMS of active and inactive biosimilars

HOS biocompatibility by MMS of active and inactive biosimilars

Learn how to measure small differences in secondary structure of biosimilar samples (not previously possible with existing analytical techniques)
Understand the benefits of Microfluidic Modulation Spectroscopy in a QC environment and for Biosimilar HOS studies
Get an overview of the analytical toolkit for HOS studies, and how Microfluidic Modulation Spectroscopy fits into the workflow

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Biophysical Characterization Of Biologics

In this webinar you will learn:
Measuring kinetics in biofluids does provide valuable insights into a drug’s efficacy
How can I best characterize antibody-drug conjugates using biochemical and biophysical techniques?
Determination of level of payload and site of conjugation of ADCs using LC/MS.

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Application Notes & Whitepapers

Using Microfluidic Modulation Spectroscopy to Determine the Structural Effect of pH on the Peptide Hormone Insulin

Using Microfluidic Modulation Spectroscopy to Determine the Structural Effect of pH on the Peptide Hormone Insulin

December 1, 2020

Secondary structure characterization is an essential part of drug development, however, the tools for measuring secondary structure of small proteins and peptides are limited.

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Detecting Protein Conformational Change Due to Ligand Binding and Stabilization Using MMS

Detecting Protein Conformational Change Due to Ligand Binding and Stabilization Using MMS

December 1, 2020

Ligand binding can affect the function of proteins and often causes conformational change in the protein target.

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Assessment of Quantitation Linearity for Bovine Serum Albumin Using MMS

Assessment of Quantitation Linearity for Bovine Serum Albumin Using MMS

December 1, 2020

Microfluidic Modulation Spectroscopy (MMS) is a revolutionary new technology capable of highly sensitive and reproducible measurements of protein secondary structure using IR absorbance in the Amide I band (1700-1600 cm-1).

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Publications

Pfizer customer story

Automated, High-Throughput Infrared Spectroscopy for Secondary Structure Analysis of Protein Biopharmaceuticals

August 3, 2020

The Journal of Pharmaceutical Sciences published a paper authored by a team at Pfizer featuring the AQS³pro.

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Applying Microfluidic Modulation Spectroscopy in Vaccine Formulation to Identify Intermolecular Beta-sheet Aggregation of Antigens

July 1, 2020

American Pharmaceutical Review Publishes Article On MMS Co Authored With Merck.

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Determining Spectroscopic Quantitation Limits for Misfolded Structures

January 15, 2020

A team led by Brent Kendrick at KBI Biopharma, compare and assess FTIR and Circular Dichroism with Microfluidic Modulation Spectroscopy (RedShiftBio) for their ability to detect the presence and quantify the amount of the misfolded structure. in this Journal of Pharmaceutical Sciences paper.

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Articles

In My Viewv

Fast and Furious HOS Analysis?

September 3, 2020

The Analytical Scientist publishes “In My View” By Jeff Zonderman of RedShiftBio.
Infrared spectroscopy is a useful technique for higher order structure analysis in the biopharmaceutical industry, but conventional systems lack pace and performance. It’s time for microfluidic modulation spectroscopy.

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Shaping IR Spectroscopy into a Powerful Tool for Biopharma Characterizations

May 1, 2020

Biopharm International publishes a peer reviewed paper co-authored by Higher Order Structure group at Amgen.

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Innovative Spectroscopy Is Enhancing Protein Structure Determination

April 23, 2020

Karen Steward from Technology Networks Interviews Julien Bradley on MMS.

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