Learn More About Microfluidic Modulation Spectroscopy

Keep up-to-date on the latest developments in Microfluidic Modulation Spectroscopy (MMS), biophysical characterization and RedShiftBio by regularly visiting us here. On this page you will find our comprehensive resources, highlights from new papers and other interesting materials that will help you characterize proteins.

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Webinars

Physicochemical Characterization of Antibody-Drug Conjugates

Physicochemical Characterization of Antibody-Drug Conjugates:   Webinar Length: 1 hourBroadcast Date: May 13, 2021Time: 11am ESTHost: LabRoots In this webinar you will learn: Analysis of the higher order structure (HOS) of therapeutic antibodies and antibody drug conjugates. Study of the effects in secondary structure of conjugated proteins. How the AQS3pro, with Microfluidic Modulation Spectroscopy, provides reliability, increased sensitivity and … “Physicochemical Characterization of Antibody-Drug Conjugates”

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Automated Analysis of Protein Secondary Structure Changes Due To Ligand Binding Using Microfluidic Modulation Spectroscopy

Automated Analysis of Protein Secondary Structure Changes Due To Ligand Binding Using Microfluidic Modulation Spectroscopy

Automated Analysis of Protein Secondary Structure Changes Due To Ligand Binding Using Microfluidic Modulation Spectroscopy Webinar Length: 1 hour Broadcast Date: April 6, 2021 Time: 1pm EST Host: CHI   In this webinar you will learn: The importance of determining the secondary structure of proteins with and without ligands for a more complete understanding of … “Automated Analysis of Protein Secondary Structure Changes Due To Ligand Binding Using Microfluidic Modulation Spectroscopy”

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HOS biocompatibility by MMS of active and inactive biosimilars

HOS biocompatibility by MMS of active and inactive biosimilars

Learn how to measure small differences in secondary structure of biosimilar samples (not previously possible with existing analytical techniques)
Understand the benefits of Microfluidic Modulation Spectroscopy in a QC environment and for Biosimilar HOS studies
Get an overview of the analytical toolkit for HOS studies, and how Microfluidic Modulation Spectroscopy fits into the workflow

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Application Notes & Whitepapers

Detection of Pressure Induced Aggregation Using MMS App note

Detection of Pressure-Induced Aggregation Using Microfluidic Modulation Spectroscopy (MMS)

April 8, 2021

Detection of Pressure-Induced Aggregation Using MicrofluidicModulation Spectroscopy (MMS) The ability to detect protein aggregation is important at all stages of drug development. Early detection of aggregation is most desirable to inform development decisions since aggregation can negatively affect the functionality of a protein. Application Note Introduction Protein aggregation is a recognized signal of instability and … “Detection of Pressure-Induced Aggregation Using Microfluidic Modulation Spectroscopy (MMS)”

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Using Microfluidic Modulation Spectroscopy to Determine the Structural Effect of pH on the Peptide Hormone Insulin

Using Microfluidic Modulation Spectroscopy to Determine the Structural Effect of pH on the Peptide Hormone Insulin

December 1, 2020

Secondary structure characterization is an essential part of drug development, however, the tools for measuring secondary structure of small proteins and peptides are limited.

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Detecting Protein Conformational Change Due to Ligand Binding and Stabilization Using MMS

Detecting Protein Conformational Change Due to Ligand Binding and Stabilization Using MMS

December 1, 2020

Ligand binding can affect the function of proteins and often causes conformational change in the protein target.

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Publications

Pfizer customer story

Automated, High-Throughput Infrared Spectroscopy for Secondary Structure Analysis of Protein Biopharmaceuticals

August 3, 2020

The Journal of Pharmaceutical Sciences published a paper authored by a team at Pfizer featuring the AQS³pro.

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Applying Microfluidic Modulation Spectroscopy in Vaccine Formulation to Identify Intermolecular Beta-sheet Aggregation of Antigens

July 1, 2020

American Pharmaceutical Review Publishes Article On MMS Co Authored With Merck.

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Determining Spectroscopic Quantitation Limits for Misfolded Structures

January 15, 2020

A team led by Brent Kendrick at KBI Biopharma, compare and assess FTIR and Circular Dichroism with Microfluidic Modulation Spectroscopy (RedShiftBio) for their ability to detect the presence and quantify the amount of the misfolded structure. in this Journal of Pharmaceutical Sciences paper.

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Articles

Pharm Tech Cover

Focusing on Accelerated Formulation Strategies – PharmTech.com

May 4, 2021

Felicity Thomas from Pharmaceutical Technology Europe discussed accelerated formulation strategies with Jeff Zonderman CCO at RedShiftBio.

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Making Secondary Structure a Priority in Bioprocessing

Making Secondary Structure a Priority in Bioprocessing

March 22, 2021

Mike May from Genetic Engineering & Biotechnology News interviews Jeff Zonderman CCO at RedShiftBio on Making Secondary Structure a Priority in Bioprocessing

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Developing a New Carrier Protein for Conjugate Vaccines

Developing a New Carrier Protein for Conjugate Vaccines: Analytical Strategies for Similarity Testing and Formulation Development

March 4, 2021

Pharmaceutical Outsourcing publishes an article by RedShiftBio and FinaBio (Fina Biosolutions LLC) on Developing a New Carrier Protein for Conjugate Vaccines: Analytical Strategies for Similarity Testing and Formulation Development.

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Interviews

Sandeep Kondaveeti

An Interview with Sandeep Kondaveeti, Research and Development Scientist at Teva Pharmaceuticals

March 17, 2021

We sat down over a virtual cup of coffee to interview Sandeep Kondaveeti, Research and Development Scientist at Teva Pharmaceuticals. His research expertise is in synthesis and characterization of inorganic / organic compounds, nano-materials, and protein complexes. Editor:I understand you currently work in the area of biological drug product development and formulation; can you tell … “An Interview with Sandeep Kondaveeti, Research and Development Scientist at Teva Pharmaceuticals”

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Shawn Owen

An Interview with Shawn Owen, Assistant Professor of Pharmaceutical Chemistry at the University of Utah

January 30, 2021

We sat down over a virtual cup of coffee to interview Dr. Shawn Owen, Assistant Professor of Pharmaceutical Chemistry at the University of Utah. Owen is an experienced pharmaceutical scientist with a demonstrated history of success in the higher education industry. Skilled in antibody engineering and bio-conjugation chemistry applied to developing therapeutic and diagnostic platforms. … “An Interview with Shawn Owen, Assistant Professor of Pharmaceutical Chemistry at the University of Utah”

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Chris Roberts

An Interview with Chris Roberts, Professor of Chemical and Biomolecular Engineering at the University of Delaware (UD)

December 30, 2020

We sat down in December 2020 over a virtual cup of coffee to interview Chris Roberts, Professor of Chemical and Biomolecular Engineering at the University of Delaware (UD). He received a Bachelors of Chemical Engineering degree from UD, and a Ph.D. in Chemical Engineering from Princeton University. His research includes experimental and theoretical fundamentals and … “An Interview with Chris Roberts, Professor of Chemical and Biomolecular Engineering at the University of Delaware (UD)”

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