Learn More About Microfluidic Modulation Spectroscopy
Keep up-to-date on the latest developments in Microfluidic Modulation Spectroscopy (MMS), biophysical characterization and RedShiftBio by regularly visiting us here. On this page you will find our comprehensive resources, highlights from new papers and other interesting materials that will help you characterize proteins.
Webinars
Automated Analysis of Protein Secondary Structure Changes Due To Ligand Binding Using Microfluidic Modulation Spectroscopy
Automated Analysis of Protein Secondary Structure Changes Due To Ligand Binding Using Microfluidic Modulation Spectroscopy Webinar Length: 1 hour Broadcast Date: February 9, 2021 Time: 11am EST Host: CHI In this webinar you will learn: The importance of determining the secondary structure of proteins with and without ligands for a more complete understanding of … “Automated Analysis of Protein Secondary Structure Changes Due To Ligand Binding Using Microfluidic Modulation Spectroscopy”
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HOS biocompatibility by MMS of active and inactive biosimilars
Learn how to measure small differences in secondary structure of biosimilar samples (not previously possible with existing analytical techniques)
Understand the benefits of Microfluidic Modulation Spectroscopy in a QC environment and for Biosimilar HOS studies
Get an overview of the analytical toolkit for HOS studies, and how Microfluidic Modulation Spectroscopy fits into the workflow
Biophysical Characterization Of Biologics
In this webinar you will learn:
Measuring kinetics in biofluids does provide valuable insights into a drug’s efficacy
How can I best characterize antibody-drug conjugates using biochemical and biophysical techniques?
Determination of level of payload and site of conjugation of ADCs using LC/MS.
Posters
Confident Differentiation of <2% changes in Secondary Structure to Compare Batch-to-Batch Activity using Microfluidic Modulation Spectroscopy (MMS)
Dr Patrick King & Dr Mike Williams RedShiftBio & Susana De Jesús Acosta, Dr Roser Llevadot, BioKit
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Microfluidic Modulation Spectroscopy for Protein Characterization A Case Study with EcoCRM, CRM197 Carrier Protein
Andrew Lees, Min-Ju Chang and Libo Wang
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Pressure-perturbation of protein secondary structure coupled with Microfluidic Modulation Spectroscopy – a powerful platform for biopharmaceutical formulations development
Vera Gross, Gary Smejkal, Nicole Cutri, Alexander Lazarev (Pressure Biosciences) Libo Wang, John Linnan, Matthew McGann, Jeffrey Zonderman, (RedShiftBio)
READ MOREApplication Notes & Whitepapers
Detecting Protein Conformational Change Due to Ligand Binding and Stabilization Using MMS
Ligand binding can affect the function of proteins and often causes conformational change in the protein target.
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Assessment of Quantitation Linearity for Bovine Serum Albumin Using MMS
Microfluidic Modulation Spectroscopy (MMS) is a revolutionary new technology capable of highly sensitive and reproducible measurements of protein secondary structure using IR absorbance in the Amide I band (1700-1600 cm-1).
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Secondary Structure Analysis of NIST Monoclonal Antibody Reference Material 8671 by Microfluidic Modulation Spectroscopy
In 2016 the National Institute of Standards and Technology (NIST) made NISTmAb Reference Material (RM) 8671 commercially available for the evaluation of methods used to characterize the structure of monoclonal antibodies.
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Automated, High-Throughput Infrared Spectroscopy for Secondary Structure Analysis of Protein Biopharmaceuticals
The Journal of Pharmaceutical Sciences published a paper authored by a team at Pfizer featuring the AQS³pro.
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Applying Microfluidic Modulation Spectroscopy in Vaccine Formulation to Identify Intermolecular Beta-sheet Aggregation of Antigens
American Pharmaceutical Review Publishes Article On MMS Co Authored With Merck.
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Determining Spectroscopic Quantitation Limits for Misfolded Structures
A team led by Brent Kendrick at KBI Biopharma, compare and assess FTIR and Circular Dichroism with Microfluidic Modulation Spectroscopy (RedShiftBio) for their ability to detect the presence and quantify the amount of the misfolded structure. in this Journal of Pharmaceutical Sciences paper.
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Fast and Furious HOS Analysis?
The Analytical Scientist publishes “In My View” By Jeff Zonderman of RedShiftBio.
Infrared spectroscopy is a useful technique for higher order structure analysis in the biopharmaceutical industry, but conventional systems lack pace and performance. It’s time for microfluidic modulation spectroscopy.
Shaping IR Spectroscopy into a Powerful Tool for Biopharma Characterizations
Biopharm International publishes a peer reviewed paper co-authored by Higher Order Structure group at Amgen.
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Innovative Spectroscopy Is Enhancing Protein Structure Determination
Karen Steward from Technology Networks Interviews Julien Bradley on MMS.
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