We sat down over a virtual cup of coffee in August 2020 to interview Jason Lin, who has recently joined RedShiftBio as Senior Field Application Scientist.
Editor: Hi Jason, welcome to the team! Can you tell us a bit about your background? What was your journey to working at RSB?
JL: Spectroscopy has always been a part of my education and work. While pursuing my bachelors at University of California, Los Angeles for example, I used fluorescence spectroscopy to probe the conformation of fluorescent polymers encapsulated in viral capsids. Time-Correlated Single Photon Counting and light scattering have also been part of my toolkit. I am now excited to use Microfluidic Modulation Spectroscopy to measure the higher order structure of proteins.
Editor: Can you tell us a bit about your role at RSB?
JL: As the Senior Field Application Scientist I directly support customers in the field by providing informational seminars, demonstrations, and training. I also provide support to the marketing department via webinars and application notes.
Editor: How is the applications team adapting to the pandemic?
JL: The pandemic has made it challenging to hold in-person seminars, demonstrations, installations, and technical support. For customers that cannot accept visitors we are able to support them via virtual meetings and screen sharing software. For customers that do allow visitors, we maintain social distancing by having the RSB representative perform the installation alone. This is then followed up with a training session either with a small socially-distanced group or virtually.
Editor: what benefits do you see from the pandemic-induced market changes?
JL: The pandemic has raised the need for scientific instrumentation that can speed up the formulation, processing, and development of treatments and vaccines. The AQS3pro by RedShiftBio has several features that make it uniquely suited for this application. For one, the AQS3pro enables users to easily run multiple samples in replicate on a 96 well plate which boosts productivity and reliability. It is compatible with a broad range of sample concentrations and excipients which enables the user to measure the final formulation without dilution or dialysis. The instrument also makes it easy for the user to control the hardware and software from their home office which is great for labs that must limit the number of people in the laboratory.
Editor: What excites you most about the technology?
JL: The most exciting aspect of AQS3pro is its ability to reach similarity scores >99% which is a significant improvement over conventional methods such as CD and FTIR to measure similarity. The ability to measure a high similarity score is essential for lot-to-lot comparisons also when comparing an originator vs. biosimilar. A recent publication by KBI Biopharma found that the AQS3pro was able to detect <1% changes in higher order structure which is 30 times more sensitive to FTIR and 5 times more sensitive than CD.
Editor: If you could say one thing to potential users of the AQS3pro, what would it be?
JL: The high reproducibility of AQS3pro will enable you to detect the slightest changes in higher order structure.
Editor: What do you like to do in your free time?
JL: In my free time I like to catch up with friends over new foods, sweet drinks, and now zoom.
Editor: Thanks Jason!